31st European Meeting of The Toxicology Forum

Topics:

ICH Safety Guidelines for Pharmaceuticals - New Developments and European Aspects

• The ICH Process, Its Impact and Updates on ICH Safety Guidelines

• The Consideration of Three R's in the ICH Safety Guidelines - a Focus of the Commission

• The Revision of the ICH Guideline on Safety Studies to Cover Clinical Trials

• New Genotoxicity Testing Concepts Introduced with the Revision of the ICH Genotoxicity Guidelines

• New ICH Guideline for Animal Safety Testing for Anti Cancer Agents

Special Aspects of Nanoparticle Risk Assessment

• Inhalation Exposure

• Dermal Exposure

• Oral Exposure

• Nanomedicine

• Physicochemical/Structural Impact on Toxicology

• View of the European Food Safety Authority

       Prediction of Skin Sensitization Potential of Chemicals             
      (in silico, in vitro, in vivo Methods)

• “Sens-it-iv” 6^th Framework Program Activities on the Development of Alternative Methods for Prediction of Skin Sensitization

• COLIPA Strategy for Replacing Animal Testing for Prediction of Skin Sensitization

• Validation of Reduced and Non-Radioactive LLNA methods

• Integrated Approaches for Prediction of Skin Sensitization of Chemicals

• Regulatory Perspective on the Use of Non-Animal Methods for Prediction of Skin Sensitization

Perfluorinated Fatty Acids Analogs – A Toxicologically Challenging Class of Chemicals

• Exposure to Perfluorinated Chemicals in Man

• Interspecies Differences of the Kinetics of PFOA and PFOS

• Differential Activation of Nuclear Receptors and Hepatocarcinogenesis

• Reproductive Toxicology in the Rat

• Perfluorinated Chemicals and Fetal Growth

• Suppression of Adaptive Immune Response by Perfluoro Octanic Acid?

 Updates:

• Formaldehyde

• The Record of Precautionary Principle in EU Case Law